Iwasaki Yoshiko, Yamato Hideyuki
Department of Health Sciences, Oita University of Nursing and Health Sciences, Japan.
Clin Calcium. 2014 Dec;24(12):1809-14.
Chronic kidney disease (CKD) patients have an extremely increased risk of fragility fractures, but the underling pathophysiological mechanisms remain obscure. Recently, the progresses of analysis technology have revealed the changes of bone quality in CKD condition. In particular, we can observe the characteristic changes of bone microarchitecture and bone chemical compositions in both human bone biopsy samples and experimental animal bones. Here, I will provide a short review on these bone quality factors and discuss on the relationship between bone quality and fracture in CKD patients.
慢性肾脏病（CKD）患者发生脆性骨折的风险极高，但其潜在的病理生理机制仍不清楚。最近，分析技术的进展揭示了CKD状态下骨质量的变化。特别是，我们可以在人类骨活检样本和实验动物骨骼中观察到骨微结构和骨化学成分的特征性变化。在此，我将对这些骨质量因素进行简要综述，并探讨CKD患者骨质量与骨折之间的关系。
