Mizobuchi Masahide, Inoue Takashi
Division of nephrology, Department of Medicine, Showa University School of Medicine, Japan.
Clin Calcium. 2014 Dec;24(12):1825-30.
Calcimimetics have beneficial effects on not only secondary hyperparathyroidism, but also control of serum calcium and phosphate levels. Development of novel calcimimetics is progressing. Basic studies have demonstrated the direct effect of calcimimetics on the vascular tissues, which may contribute to the improvement of vascular calcification. Further studies are required to evaluate the usefulness of calcimimetics for mortality.
拟钙剂不仅对继发性甲状旁腺功能亢进有有益作用，而且对血清钙和磷水平的控制也有作用。新型拟钙剂的研发正在进行中。基础研究已证明拟钙剂对血管组织有直接作用，这可能有助于改善血管钙化。需要进一步研究来评估拟钙剂对死亡率的效用。
