精氨酸972胰岛素受体底物-1多态性与类风湿关节炎的风险及严重程度
Arg972 insulin receptor substrate-1 polymorphism and risk and severity of rheumatoid arthritis.
作者信息
Zhao Hongjun, Liu Shiqing, Long Mei, Peng Lijuan, Deng Hongxiang, You Yunhui
机构信息
Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, China.
出版信息
Int J Rheum Dis. 2016 Feb;19(2):141-5. doi: 10.1111/1756-185X.12366. Epub 2014 Nov 25.
AIM
To explore the association between the Arg(972) insulin receptor substrate (IRS)-1 polymorphism (rs1801278) and the risk and disease activity/severity of rheumatoid arthritis (RA).
METHOD
We genotyped the Arg(972) IRS-1 polymorphism in 871 pairs of age-, sex-, body mass index-, residence area- and current smoking status-matched RA patients and controls. We assessed RA severity using the disease activity score of 28 joints (DAS28).
RESULTS
The AA (homozygous Arg(972) IRS-1) and GA (heterozygous Arg(972) IRS-1) genotypes were significantly associated with high risk of RA with or without adjustment for comorbidities (P < 0.001). The A allele was significantly associated with high risk of RA (P < 0.001). The AA genotype was significantly associated with high/severe RA activity (P < 0.001), while the GG genotype (wild type IRS-1) had protective effects.
CONCLUSION
The Arg(972) IRS-1 polymorphism is associated with increased risk and disease activity/severity of RA, and therefore may be a potential prognostic factor for RA. This study adds novel insights into the pathogenesis of RA.
目的
探讨精氨酸（972）胰岛素受体底物（IRS）-1基因多态性（rs1801278）与类风湿关节炎（RA）的风险及疾病活动度/严重程度之间的关联。
方法
我们对871对年龄、性别、体重指数、居住地区和当前吸烟状况相匹配的RA患者及对照进行了精氨酸（972）IRS-1基因分型。我们使用28个关节疾病活动评分（DAS28）评估RA的严重程度。
结果
无论是否对合并症进行校正，AA（纯合子精氨酸（972）IRS-1）和GA（杂合子精氨酸（972）IRS-1）基因型均与RA的高风险显著相关（P < 0.001）。A等位基因与RA的高风险显著相关（P < 0.001）。AA基因型与高/重度RA活动显著相关（P < 0.001），而GG基因型（野生型IRS-1）具有保护作用。
结论
精氨酸（972）IRS-1基因多态性与RA风险增加及疾病活动度/严重程度相关，因此可能是RA的一个潜在预后因素。本研究为RA的发病机制增添了新的见解。
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