麻醉性镇痛药的中枢作用。II. 运动活性与麻醉性镇痛药
Central action of narcotic analgesics. II. Locomotor activity and narcotic analgesics.
作者信息
Fidecka S, Malec D, Langwiński R
出版信息
Pol J Pharmacol Pharm. 1978 Jan-Feb;30(1):5-16.
The effect of morphine, codeine, fentanyl and pentazocine on locomotor activity of rats and mice and open-field performance of rats were tested. All the analgesics tested produced a depressive action in the rat. In mice a depressive action was produced by pentazocine and codeine. Fentanyl increased the exploratory and basal locomotor activity of mice. Morphine increased the exploratory activity, but, given at doses of 2.5 and 10 mg/kg decreased the basal locomotor activity. The increase of locomotor activity in mice by morphine and fentanyl is caused by an indirect stimulation of catecholamine receptors.
测试了吗啡、可待因、芬太尼和喷他佐辛对大鼠和小鼠运动活性以及大鼠旷场行为表现的影响。所有受试镇痛药均对大鼠产生抑制作用。在小鼠中，喷他佐辛和可待因产生抑制作用。芬太尼增加了小鼠的探索性和基础运动活性。吗啡增加了探索性活性，但给予2.5和10mg/kg剂量时降低了基础运动活性。吗啡和芬太尼使小鼠运动活性增加是由儿茶酚胺受体的间接刺激所致。
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