韩国普通人群中载脂蛋白E多态性与慢性肾脏病的关联：东古研究

Association between Apolipoprotein E Polymorphism and Chronic Kidney Disease in the Korean General Population: Dong-gu Study.

作者信息

Choi Seong-Woo, Kweon Sun-Seog, Choi Jin-Su, Rhee Jung-Ae, Lee Young-Hoon, Nam Hae-Sung, Jeong Seul-Ki, Park Kyeong-Soo, Ryu So-Yeon, Kim Hee Nam, Song Hye-Rim, Shin Min-Ho

机构信息

Department of Preventive Medicine, Chosun University School of Medicine, Gwangju, Korea.

Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea. ; Jeonnam Regional Cancer Center, Chonnam National University Hwasun Hospital, Hwasun, Korea.

出版信息

Korean J Fam Med. 2014 Nov;35(6):276-82. doi: 10.4082/kjfm.2014.35.6.276. Epub 2014 Nov 21.

DOI:10.4082/kjfm.2014.35.6.276

PMID:25426275

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4242905/

Abstract

BACKGROUND

Few studies have investigated the association between Apolipoprotein E (APOE) polymorphisms and chronic kidney disease (CKD) in the general population, and their results are inconsistent.

METHODS

The current study population was composed of 9,033 subjects aged ≥ 50 years who participated in the baseline survey of the Dong-gu Study, which was conducted in Korea between 2007 and 2010. APOE polymorphisms were identified by polymerase chain reaction, and the estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease equation.

RESULTS

Individuals with the APOE E2 allele had significantly lower total and low density lipoprotein cholesterol levels, those with the APOE E4 allele had lower high density lipoprotein (HDL) cholesterol levels, and those with the APOE E3 allele had lower log-triglyceride levels. Adjusting for covariates (sex, age, body mass index, smoking, systolic blood pressure, hypertension, diabetes, total cholesterol, HDL cholesterol, log-transformed triglycerides, and log-transformed albumin to creatinine ratio), mean eGFR was not significantly different among APOE alleles (E2, 69.4 mL/min/1.73 m(2); E3, 69.5 mL/min/1.73 m(2); E4, 69.4 ml/min/1.73 m(2); P = 0.873). Additionally, the odds ratios (ORs) indicated that APOE polymorphisms were not independent risk factors for CKD (OR, 1.07; 95% confidence interval [CI], 0.91 to 1.26 for the E2 vs. E3 allele; OR, 1.01; 95% CI, 0.88 to 1.16 for the E4 vs. E3 allele).

CONCLUSION

APOE polymorphisms were not associated with either eGFR or CKD in the general Korean population.

摘要

背景

很少有研究在普通人群中调查载脂蛋白E（APOE）基因多态性与慢性肾脏病（CKD）之间的关联，且研究结果并不一致。

方法

本研究人群由9033名年龄≥50岁的受试者组成，这些受试者参与了2007年至2010年在韩国进行的东谷研究的基线调查。通过聚合酶链反应鉴定APOE基因多态性，并使用肾脏病饮食改良方程计算估计肾小球滤过率（eGFR）。

结果

携带APOE E2等位基因的个体总胆固醇和低密度脂蛋白胆固醇水平显著较低，携带APOE E4等位基因的个体高密度脂蛋白（HDL）胆固醇水平较低，携带APOE E3等位基因的个体甘油三酯对数水平较低。在对协变量（性别、年龄、体重指数、吸烟、收缩压、高血压、糖尿病、总胆固醇、HDL胆固醇、甘油三酯对数转换值以及白蛋白与肌酐比值对数转换值）进行校正后，不同APOE等位基因（E2，69.4 mL/min/1.73 m²；E3，69.5 mL/min/1.73 m²；E4，69.4 ml/min/1.73 m²；P = 0.873）之间的平均eGFR无显著差异。此外，比值比（OR）表明APOE基因多态性不是CKD的独立危险因素（E2与E3等位基因相比，OR为1.07；95%置信区间[CI]为0.91至1.26；E4与E3等位基因相比，OR为1.01；95%CI为0.88至1.16）。