Baker Wesley B, Parthasarathy Ashwin B, Busch David R, Mesquita Rickson C, Greenberg Joel H, Yodh A G
Dept. Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Dept. Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA ; Div. of Neurology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Biomed Opt Express. 2014 Oct 28;5(11):4053-75. doi: 10.1364/BOE.5.004053. eCollection 2014 Nov 1.
We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.
我们基于扩散相关光谱(DCS)测量开发并验证了一种用于血流的修正比尔-朗伯定律。新公式能够根据在单个或多个延迟时间采集的时间强度自相关函数数据进行血流监测。因此,光学血流测量的速度可以大幅提高。该方案有助于在光传播为扩散或非扩散的几何形状中对高散射组织进行血流监测,并且特别适合与采用差分流量信号以减少浅表组织贡献的压力测量范式一起使用。