Claudet Isabelle, Cortey Caroline, Honorat Raphaele, Franchitto Nicolas
From the *Pediatric Emergency Department, Children University Hospital and †Regional Poison Center, Purpan University Hospital, Toulouse, France.
Pediatr Emerg Care. 2015 Jan;31(1):44-6. doi: 10.1097/PEC.0000000000000301.
Minoxidil hair formulation is commonly used for the treatment of male or female androgenic alopecia. This over-the-counter product is wrongly considered safe. The ingestion of a few milliliters by a child can lead to significant intoxication. We report a case of significant intoxication after the ingestion of topical minoxidil (Alopexy; Pierre Fabre Laboratoires, SA, Switzerland). A 7-year-old girl, who accidentally ingested a teaspoon of minoxidil hair solution, presented to the pediatric emergency department for emesis. At admission, she had a blood pressure of 86/56 mm Hg and a pulse of 149 beats per minute. Hypotension lasted 40 hours with the lowest value 24 hours after ingestion (79/33 mm Hg). She presented electrocardiogram changes (sinus tachycardia and flattening T-waves) but normal cardiac enzymes. Infusion of 20 mL/kg of normal saline fluid had no hemodynamic effect. Her blood pressure normalized on day 2. Minoxidil topical solution is an unsafe product for children. This formulation should be strictly kept out of reach of children and manufacturers should enhance child-resistance security of packaging. The over-the-counter availability must be questioned.
米诺地尔生发制剂常用于治疗男性或女性雄激素性脱发。这种非处方产品被错误地认为是安全的。儿童摄入几毫升就可能导致严重中毒。我们报告一例因误服外用米诺地尔（Alopexy；瑞士皮埃尔·法布尔实验室公司）导致严重中毒的病例。一名7岁女孩意外误服一茶匙米诺地尔生发溶液后，前往儿科急诊科就诊，表现为呕吐。入院时，她的血压为86/56毫米汞柱，脉搏为每分钟149次。低血压持续了40小时，摄入后24小时血压最低（79/33毫米汞柱）。她出现了心电图改变（窦性心动过速和T波低平），但心肌酶正常。输注20毫升/千克的生理盐水对血流动力学没有影响。她的血压在第2天恢复正常。外用米诺地尔溶液对儿童来说是不安全的产品。该制剂应严格放在儿童接触不到的地方，制造商应加强包装的防儿童开启安全设计。非处方可得性必须受到质疑。
