SLITRK5基因与抽动秽语综合征的关联研究。
Association study of the SLITRK5 gene and Tourette syndrome.
作者信息
Zhang Kevin, Feng Yu, Wigg Karen G, Sandor Paul, Barr Cathy L
机构信息
aGenetics and Development Division bDivision of Brain, Imaging and Behaviour - Systems Neuroscience, Toronto Western Research Institute, University Health Network cProgram in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada.
出版信息
Psychiatr Genet. 2015 Feb;25(1):31-4. doi: 10.1097/YPG.0000000000000067.
Tourette syndrome (TS) and obsessive-compulsive disorder commonly occur together. Family studies indicate shared genetic risk factors. SLITRK5, one of a family of six SLITRK genes, has been suggested as a possible candidate gene contributing towards obsessive-compulsive disorder on the basis of the mouse knockout model that shows excessive grooming behaviours that are alleviated with fluoxetine. In this study, we tested the SLITRK5 gene as a candidate for TS in a family-based sample with 377 affected children. Using single nucleotide polymorphisms tagging the gene, we did not find any evidence supporting the association of TS and SLITRK5.
抽动秽语综合征（TS）与强迫症常同时出现。家族研究表明存在共同的遗传风险因素。SLITRK5是六个SLITRK基因家族中的一员，基于小鼠基因敲除模型显示出过度梳理行为且氟西汀可缓解该行为，它被认为是导致强迫症的一个可能候选基因。在本研究中，我们在一个有377名患病儿童的家系样本中，将SLITRK5基因作为抽动秽语综合征的候选基因进行检测。使用标记该基因的单核苷酸多态性，我们未发现任何支持抽动秽语综合征与SLITRK5基因关联的证据。
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