免疫组化生物标志物在泌尿外科手术病理学中的应用。
The application of immunohistochemical biomarkers in urologic surgical pathology.
作者信息
Wilkerson Myra L, Lin Fan, Liu Haiyan, Cheng Liang
机构信息
From the Department of Laboratory Medicine, Geisinger Medical Center, Danville, Pennsylvania (Drs Wilkerson, Lin, and Liu);
出版信息
Arch Pathol Lab Med. 2014 Dec;138(12):1643-65. doi: 10.5858/arpa.2014-0078-RA.
CONTEXT
Tumors of the genitourinary tract can be diagnostically challenging, particularly in core biopsies and cystoscopic biopsies with limited material. Immunohistochemistry is a valuable tool to use when morphology alone is insufficient for diagnosis.
OBJECTIVES
To review tumors and benign lesions of the kidney, urinary bladder, prostate gland, testis, and paratesticular structures with an emphasis on difficult differential diagnoses, as well as staining patterns in normal tissue. Recommended immunohistochemical stain panels are discussed that can assist in the diagnostic workup.
DATA SOURCES
Review of current literature.
CONCLUSIONS
Immunohistochemistry is a valuable tool, assisting in the diagnosis of problematic tumors and benign lesions of the genitourinary tract.
背景
泌尿生殖道肿瘤在诊断上可能具有挑战性，尤其是在取材有限的核心活检和膀胱镜活检中。当仅靠形态学不足以进行诊断时，免疫组织化学是一种有价值的工具。
目的
回顾肾脏、膀胱、前列腺、睾丸和睾丸旁结构的肿瘤及良性病变，重点关注困难的鉴别诊断以及正常组织中的染色模式。讨论了推荐的免疫组织化学染色组合，其有助于诊断检查。
数据来源
对当前文献的综述。
结论
免疫组织化学是一种有价值的工具，有助于诊断泌尿生殖道有问题的肿瘤和良性病变。
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