Elizavetina G A, Vinnitskiĭ L I, Vorob'eva N T, Chorbinskaia S A, Izmalkova N M
Ter Arkh. 1989;61(2):46-8.
Hyperbaric oxygenation (HBO) and pyridinolcarbamat were mainly applied in the treatment of elderly patients with peptic ulcer attended by coronary heart disease and atherosclerosis. To evaluate the condition of intracellular regulators after the treatment, a study was made of the time-course of changes in the content of cyclic nucleotides in blood plasma and gastric mucosa. The use of HBO in the treatment of peptic ulcer raised the efficacy of the multimodality therapy and accelerated the epithelization of erosive and ulcerative defects. The use of pyridinolcarbamat turned to produce a beneficial therapeutic effect and to be protective with respect to the gastric mucosa. Thus it was found desirable to apply the drug to the treatment of ulcers mainly occurring in the stomach. The changes in the content of cyclic nucleotides in blood plasma and gastric mucosa may play an important role in the realization of positive metabolic changes in gastric mucosa, induced by pyridinolcarbamat and HBO in peptic ulcer patients.
高压氧疗（HBO）和卡巴马唑主要应用于伴有冠心病和动脉粥样硬化的老年消化性溃疡患者的治疗。为评估治疗后细胞内调节因子的状况，对血浆和胃黏膜中环核苷酸含量的时间变化过程进行了研究。使用HBO治疗消化性溃疡提高了多模式疗法的疗效，并加速了糜烂性和溃疡性缺损的上皮化。使用卡巴马唑产生了有益的治疗效果，并对胃黏膜具有保护作用。因此，发现将该药物应用于主要发生在胃中的溃疡治疗是可取的。血浆和胃黏膜中环核苷酸含量的变化可能在卡巴马唑和HBO诱导消化性溃疡患者胃黏膜发生积极代谢变化的过程中发挥重要作用。
