Line S R, Torloni H, Junqueira L C
Department of Oral Pathology, Piracicaba Dentistry School, University of Campinas, Brazil.
Virchows Arch A Pathol Anat Histopathol. 1989;414(6):477-83. doi: 10.1007/BF00781704.
The high diversity of collagen expression and its qualitative and quantitative aspects are demonstrated in pleomorphic adenoma using electron microscopy and specific histochemical methods. Great variability was observed in the amount, distribution and characteristics of the collagen found in the various types of tissue normally present in this tumour. Both deficient polymerization and hyperpolymerization of collagen and the occurrence of desmoplasia were observed. Evidence is presented to suggest a role for localized collagenolysis in the invasiveness of this neoplasia.
利用电子显微镜和特定组织化学方法，在多形性腺瘤中证实了胶原蛋白表达的高度多样性及其定性和定量方面。在该肿瘤中通常存在的各种类型组织中发现的胶原蛋白的数量、分布和特征存在很大差异。观察到胶原蛋白的聚合不足和过度聚合以及结缔组织增生的发生。有证据表明局部胶原溶解在这种肿瘤的侵袭性中起作用。
