一种简洁合成方法用于获取奥罗星A的研究进展。
Development of a Concise Synthetic Approach to Access Oroxin A.
作者信息
Chen Haijun, He Guihua, Li Cailong, Dong Longrong, Xie Xiaobo, Wu Jianlei, Gao Yu, Zhou Jia
机构信息
College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108,China,; Tel: +86 591 22866234;
Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States, ; Tel: +1 (409) 772-9748;
出版信息
RSC Adv. 2014 Jan 1;4(85):45151-45154. doi: 10.1039/C4RA08573F.
Abstract
A novel environment-friendly method to access bioactive oroxin A through a one-pot/two-step process from naturally abundant and inexpensive baicalin is described. The procedure presented here has several advantages including clean, one-pot, synthetic ease, and large-scale feasibility. This work also provides a model strategy for rapid and diverse access to natural molecules sharing the common skeleton of this family.
摘要
描述了一种新颖的环境友好方法，可通过一锅两步法从天然丰富且廉价的黄芩苷中获取生物活性奥罗星A。这里介绍的方法具有几个优点，包括清洁、一锅法、合成简便以及大规模可行性。这项工作还为快速多样地获取具有该家族共同骨架的天然分子提供了一种模型策略。
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