Mitchell Marci R, Potenza Marc N
Department of Psychiatry, Yale University School of Medicine, New Haven, CT.
Department of Psychiatry, Yale University School of Medicine, New Haven, CT ; Department of Neurobiology, Yale University School of Medicine, New Haven, CT ; Child Study Center, Yale University School of Medicine, New Haven, CT.
Curr Addict Rep. 2014 Dec 1;1(4):309-319. doi: 10.1007/s40429-014-0037-4.
Impulsivity is associated with various psychopathologies, and elevated impulsivity is typically disadvantageous. This manuscript reviews recent investigations into the neurobiology of impulsivity using human imaging techniques and animal models. Both human imaging and preclinical pharmacological manipulations have yielded important insights into the neurobiological underpinnings of impulsivity. A more thorough understanding of the complex neurobiology underlying aspects of impulsivity may provide insight into new treatment options that target elevated impulsivity and psychopathologies such as addictions.
冲动性与多种精神病理学相关,且冲动性增强通常是不利的。本手稿回顾了近期使用人体成像技术和动物模型对冲动性神经生物学的研究。人体成像和临床前药理学操作都为冲动性的神经生物学基础提供了重要见解。对冲动性背后复杂神经生物学的更深入理解可能为针对冲动性增强及成瘾等精神病理学的新治疗选择提供思路。