Aloi Joseph, Korin Tahlia E, Murray Olivia K, Crum Kathleen I, LeFevre Katherine, Dzemidzic Mario, Hulvershorn Leslie A
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana; Adolescent Behavioral Health Research Program, Indiana University School of Medicine, Indianapolis, Indiana.
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana; Adolescent Behavioral Health Research Program, Indiana University School of Medicine, Indianapolis, Indiana.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2025 Mar 7. doi: 10.1016/j.bpsc.2025.02.013.
Children with externalizing disorders often have difficulties with impulsivity (IMP) and emotion regulation (ER). These constructs have been associated with dysfunction in the recruitment of reward-processing circuits and striatal connectivity with cortical networks. However, it is unclear to what extent co-presentations of IMP and ER are associated with differences in striatocortical connectivity.
In study 1, a latent profile analysis (LPA) was conducted in a sample of 198 youths with externalizing disorders (oppositional defiant disorder and/or conduct disorder) to investigate co-presentation of IMP and ER symptoms. Participants completed the UPPS Impulsivity Scale (UPPS) and the Emotion Regulation Checklist (ERC). LPA was applied to the subscales of the UPPS and ERC. In study 2, we examined 169 participants who completed a resting-state functional magnetic resonance imaging scan to examine differences in striatocortical connectivity between profiles.
The LPA identified 3 profiles: moderate IMP/moderate ER, high IMP/low ER, and high IMP/moderate ER. The 2 high IMP profiles were associated with greater connectivity between the posterior caudate nucleus and parietal cortex. The high IMP/low ER profile was associated with increased connectivity between the anterior caudate and anterior insula.
The current data indicate that the profiles associated with high IMP are associated with greater caudate-parietal cortex connectivity, while the profile associated with high IMP and impaired ER showed increased anterior caudate-anterior insular cortex connectivity. The current work contributes to the literature by examining the relationship between heterogeneity of externalizing symptoms and functional connectivity.
患有外化性障碍的儿童通常在冲动性（IMP）和情绪调节（ER）方面存在困难。这些构念与奖励处理回路的招募功能障碍以及纹状体与皮质网络的连接性有关。然而，尚不清楚IMP和ER的共同表现与纹状体 - 皮质连接性差异的关联程度。
在研究1中，对198名患有外化性障碍（对立违抗性障碍和/或品行障碍）的青少年样本进行了潜在剖面分析（LPA），以研究IMP和ER症状的共同表现。参与者完成了UPPS冲动性量表（UPPS）和情绪调节检查表（ERC）。LPA应用于UPPS和ERC的子量表。在研究2中，我们检查了169名完成静息态功能磁共振成像扫描的参与者，以检查不同剖面之间纹状体 - 皮质连接性的差异。
LPA确定了3种剖面：中度IMP/中度ER、高IMP/低ER和高IMP/中度ER。两种高IMP剖面与尾状核后部与顶叶皮质之间更强的连接性相关。高IMP/低ER剖面与尾状核前部与脑岛前部之间的连接性增加相关。
当前数据表明，与高IMP相关的剖面与更强的尾状核 - 顶叶皮质连接性相关，而与高IMP和受损ER相关的剖面显示尾状核前部 - 脑岛前部皮质连接性增加。当前的研究通过检查外化症状的异质性与功能连接性之间的关系，为该领域的文献做出了贡献。
