Akeju Oluwaseun, Loggia Marco L, Catana Ciprian, Pavone Kara J, Vazquez Rafael, Rhee James, Contreras Ramirez Violeta, Chonde Daniel B, Izquierdo-Garcia David, Arabasz Grae, Hsu Shirley, Habeeb Kathleen, Hooker Jacob M, Napadow Vitaly, Brown Emery N, Purdon Patrick L
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, United States.
MGH/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, United States.
Elife. 2014 Nov 28;3:e04499. doi: 10.7554/eLife.04499.
Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of unconsciousness. By using a novel combination of positron emission tomography and functional magnetic resonance imaging, we studied anesthesia-induced unconsciousness and recovery using the α₂-agonist dexmedetomidine. During unconsciousness, cerebral metabolic rate of glucose and cerebral blood flow were preferentially decreased in the thalamus, the Default Mode Network (DMN), and the bilateral Frontoparietal Networks (FPNs). Cortico-cortical functional connectivity within the DMN and FPNs was preserved. However, DMN thalamo-cortical functional connectivity was disrupted. Recovery from this state was associated with sustained reduction in cerebral blood flow and restored DMN thalamo-cortical functional connectivity. We report that loss of thalamo-cortical functional connectivity is sufficient to produce unconsciousness.
理解意识的神经基础是神经科学研究的根本。皮质-皮质连接中断被认为是无意识的主要机制。通过使用正电子发射断层扫描和功能磁共振成像的新型组合，我们使用α₂-激动剂右美托咪定研究了麻醉诱导的无意识和恢复过程。在无意识状态下，丘脑、默认模式网络（DMN）和双侧额顶叶网络（FPNs）中的脑葡萄糖代谢率和脑血流量优先降低。DMN和FPNs内的皮质-皮质功能连接得以保留。然而，DMN丘脑-皮质功能连接被破坏。从这种状态恢复与脑血流量持续减少和DMN丘脑-皮质功能连接恢复有关。我们报告丘脑-皮质功能连接的丧失足以导致无意识。
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