Shin Hye Young, Kim Jin Wook, Paek Sun Ha, Kim Dong Gyu
Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea.
Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Korea.
Neurosurg Clin N Am. 2015 Jan;26(1):31-6. doi: 10.1016/j.nec.2014.09.009.
Angiographic findings suggest that central neurocytoma (CN) might originate from neuronal cells of the subventricular zone (SVZ) around the foramen of Monro rather than from the septum pellucidum. The majority of CN cells have neuroblast characteristics. Most importantly, CN-derived tumor spheres have a phenotype of transit-amplifying type C cells, implying that these cells might arise from transformed transit-amplifying type C cells that reside in the SVZ. These CN-derived tumor spheres are also reminiscent of radial glial cells. Immunohistochemical and electrophysiologic studies show that these cells exhibit bipotential neuroglial differentiation in vitro.
血管造影结果表明，中枢神经细胞瘤（CN）可能起源于孟氏孔周围室管膜下区（SVZ）的神经元细胞，而非透明隔。大多数CN细胞具有神经母细胞特征。最重要的是，源自CN的肿瘤球具有C型过渡增殖细胞的表型，这意味着这些细胞可能起源于SVZ中转化的C型过渡增殖细胞。这些源自CN的肿瘤球也让人联想到放射状胶质细胞。免疫组织化学和电生理研究表明，这些细胞在体外表现出双潜能神经胶质分化。
