青少年系统性红斑狼疮的肺功能评估

Spirometric evaluation in juvenile systemic lupus erythematosus.

作者信息

Alam Md Mahboob, Sarkar Sumantra, Ghosh Parasar, Ray Biman, Mondal Rakesh

机构信息

Departments of Physiology and *Pediatric Rheumatology, Institute of Postgraduate Medical Education and Research, Kolkata, India. Correspondence to: Dr Md Mahboob Alam, Assistant Professor, Department of Physiology, IPGMER, 54, Alimuddin Street, Kolkata 700 016, India.

出版信息

Indian Pediatr. 2014 Nov;51(11):909-11. doi: 10.1007/s13312-014-0527-4.

DOI:10.1007/s13312-014-0527-4

PMID:25432223

Abstract

OBJECTIVE

Spirometric evaluation in juvenile systemic lupus erythematosus.

METHODS

Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC, forced expiratory flow between 25-75% of vital capacity (FEF25-75%) and peak expiratory flow rate (PEFR) of 21 patients with juvenile SLE (jSLE) were compared to controls.

RESULTS

Reduced FVC and FEF25-75% was found in 18 and 9 patients, respectively. All had normal FEV1/FVC. None had respiratory complaint. When compared to controls, patients had significantly reduced FVC [mean (SD):1.97 (0.56) vs 2.35 (0.60), P=0.002] and FEF25-75% [2.19 (0.83) vs 2.63 (0.76), P=0.028] but similar FEV1/FVC [86.87(7.03) vs 86.72 (6.35), P=0.639].

CONCLUSION

jSLE patients had significant restrictive pattern and small airway involvement.

摘要

目的

青少年系统性红斑狼疮的肺功能评估。

方法

将21例青少年系统性红斑狼疮（jSLE）患者的用力肺活量（FVC）、第1秒用力呼气容积（FEV1）、FEV1/FVC、肺活量25%-75%之间的用力呼气流量（FEF25-75%）和呼气峰值流速（PEFR）与对照组进行比较。

结果

分别在18例和9例患者中发现FVC和FEF25-75%降低。所有患者FEV1/FVC均正常。无一例有呼吸系统主诉。与对照组相比，患者的FVC[平均值（标准差）：1.97（0.56）对2.35（0.60），P=0.002]和FEF25-75%[2.19（0.83）对2.63（0.76），P=0.028]显著降低，但FEV1/FVC相似[86.87（7.03）对86.72（6.35），P=0.639]。