Kar Hemanta Kumar, Gupta Ruchi
Department of Dermatology, STD, and Leprosy, PGIMER & Dr RML Hospital, New Delhi, 110001, India.
Department of Dermatology, STD, and Leprosy, PGIMER & Dr RML Hospital, New Delhi, 110001, India.
Clin Dermatol. 2015 Jan-Feb;33(1):55-65. doi: 10.1016/j.clindermatol.2014.07.007.
Leprosy is a curable disease, having been eliminated from many countries, including India. This has been possible due to the wide availability of effective and safe drugs. Treatment of leprosy has undergone considerable changes over decades, from chaulmoogra oil in 1915 to dapsone monotherapy in 1946, then eventually to multidrug therapy (MDT) in 1982. In the last two decades, reports of resistance to all first-line drugs have appeared in the literature, with the need to conduct clinical trials using newer but highly bactericidal drugs and their combinations against Mycobacterium leprae.
麻风病是一种可治愈的疾病，在包括印度在内的许多国家已被消灭。这之所以成为可能，是因为有广泛可得的有效且安全的药物。几十年来，麻风病的治疗发生了相当大的变化，从1915年的大风子油，到1946年的氨苯砜单药治疗，然后最终在1982年发展为联合化疗（MDT）。在过去二十年里，文献中出现了对所有一线药物耐药的报告，因此有必要开展临床试验，使用更新的但具有高度杀菌作用的药物及其组合来对抗麻风分枝杆菌。
