Haseloff Reiner F, Dithmer Sophie, Winkler Lars, Wolburg Hartwig, Blasig Ingolf E
Leibniz Institute for Molecular Pharmacology, Robert Roessle-Str. 10, 13125 Berlin, Germany.
Leibniz Institute for Molecular Pharmacology, Robert Roessle-Str. 10, 13125 Berlin, Germany.
Semin Cell Dev Biol. 2015 Feb;38:16-25. doi: 10.1016/j.semcdb.2014.11.004. Epub 2014 Nov 26.
The blood-brain barrier (BBB) is formed by microvascular endothelial cells sealed by tetraspanning tight junction (TJ) proteins, such as claudins and TAMPs (TJ-associated marvel proteins, occludin and tricellulin). Claudins are the major components of the TJs. At the BBB, claudin-5 dominates the TJs by preventing the paracellular permeation of small molecules. On the other hand, TAMPs regulate the structure and function of the TJs; tricellulin may tighten the barrier for large molecules. This review aims at integrating and summarizing the most relevant and recent work on how the BBB is influenced by claudin-1, -3, -5, -12 and the TAMPs occludin and tricellulin, all of which are four-transmembrane TJ proteins. The exact functions of claudin-1, -3, -12 and TAMPs at this barrier still need to be elucidated.
血脑屏障（BBB）由微血管内皮细胞形成，这些细胞由四跨膜紧密连接（TJ）蛋白封闭，如闭合蛋白和TAMPs（TJ相关的MARVEL蛋白、闭锁蛋白和三联蛋白）。闭合蛋白是紧密连接的主要成分。在血脑屏障处，闭合蛋白-5通过阻止小分子的细胞旁渗透来主导紧密连接。另一方面，TAMPs调节紧密连接的结构和功能；三联蛋白可能会加强对大分子的屏障作用。本综述旨在整合和总结关于血脑屏障如何受到闭合蛋白-1、-3、-5、-12以及TAMPs闭锁蛋白和三联蛋白影响的最相关和最新的研究工作，所有这些都是四跨膜紧密连接蛋白。闭合蛋白-1、-3、-12和TAMPs在该屏障的确切功能仍有待阐明。
