Zucker肥胖和糖尿病大鼠循环中LOX-1配体水平升高。
Elevation of circulating LOX-1 ligand levels in Zucker obese and diabetic rats.
作者信息
Wakabayashi Ichiro, Shimomura Tomoko, Nakanishi Mamoru, Uchida Kagehiro
机构信息
Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
Department of Environmental and Preventive Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan.
出版信息
Obes Res Clin Pract. 2015 Jan-Feb;9(1):26-30. doi: 10.1016/j.orcp.2014.10.001. Epub 2014 Nov 28.
LOX-1 ligands containing apolipoprotein B (LAB) reflect ligand activity of LOX-1, which is a key molecule for initiation of atherosclerosis. The Zucker rat is a well-known model used for research on obesity and diabetes. Blood levels of LAB were compared among Zucker fatty (ZF), Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. Log-transformed LAB was significantly higher in ZF and ZDF rats than in control ZL rats, while no significant difference was found in log-transformed LAB of ZF and ZDF rats. This study for the first time demonstrated that circulating LOX-1 ligands were elevated in obesity and diabetes model rats.
含载脂蛋白B的凝集素样氧化低密度脂蛋白受体-1配体（LAB）反映了凝集素样氧化低密度脂蛋白受体-1（LOX-1）的配体活性，而LOX-1是动脉粥样硬化起始的关键分子。Zucker大鼠是用于肥胖症和糖尿病研究的著名模型。比较了Zucker肥胖（ZF）大鼠、Zucker糖尿病肥胖（ZDF）大鼠和Zucker瘦（ZL）大鼠的LAB血液水平。经对数转换的LAB在ZF和ZDF大鼠中显著高于对照ZL大鼠，而ZF和ZDF大鼠经对数转换的LAB之间未发现显著差异。本研究首次证明肥胖和糖尿病模型大鼠的循环LOX-1配体升高。
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