儿童急性白血病和癌症现代治疗的演变：20世纪70年代和80年代的探索与斗争

Evolution of modern treatment of childhood acute leukemia and cancer: adventures and battles in the 1970s and 1980s.

作者信息

Ravindranath Yaddanapudi

机构信息

Department of Pediatrics, Wayne State University School of Medicine, 3901 Beaubien Boulevard, Detroit, MI 48201, USA.

出版信息

Pediatr Clin North Am. 2015 Feb;62(1):1-10. doi: 10.1016/j.pcl.2014.09.005.

DOI:10.1016/j.pcl.2014.09.005

PMID:25435108

Abstract

This article summarizes the adventures and explorations in the 1970s and 1980s in the treatment of children with leukemia and cancer that paved the way for the current success in childhood cancers. Indeed, these were adventures and bold steps into unchartered waters. Because childhood leukemia the most common of the childhood cancers, success in childhood leukemia was pivotal in the push toward cure of all childhood cancers. The success in childhood leukemia illustrates how treatment programs were designed using clinical- and biology-based risk factors seen in the patients.

摘要

本文总结了20世纪70年代和80年代在儿童白血病和癌症治疗方面的探索历程，这些探索为目前儿童癌症治疗的成功奠定了基础。事实上，这些都是踏入未知领域的大胆尝试。由于儿童白血病是儿童癌症中最常见的类型，儿童白血病治疗的成功对于推动所有儿童癌症的治愈至关重要。儿童白血病治疗的成功表明了如何根据患者身上基于临床和生物学的风险因素来设计治疗方案。