柴胡桂枝汤抗抑郁作用及其作用机制的研究
Study on the anti-depressant effect of Chaihu Guizhi decoction and its mechinisims of actions.
作者信息
Liu Yu, Cao Chunmei, Ding Haijun
机构信息
Department of Psychology, Peking University, Beijing 100871, China.
Department of Physical Education, Tsinghua University, Beijing 100084, China.
出版信息
Afr J Tradit Complement Altern Med. 2014 Jan 28;11(2):273-6. doi: 10.4314/ajtcam.v11i2.7. eCollection 2014.
BACKGROUND
Chaihu Guizhi has the effects of treating exogenous wind-cold; alternating episodes of chills and fever; noisy nose and retching; strong headache; chest and rib-side pain, and fullness, in clinical practice, it can also be used for the treatment of depression. The objective of this paper was to study the anti-depressant effect of Chaihu Guizhi decoction and its mechanism.
MATERIALS AND METHODS
The anti-depressant effect of Chaihu Guizhi decoction was investigated by forced swimming test, tail suspension test and antagonism of reserpine hypothermia test in mice.
RESULTS
Chaihu Guizhi decoction could significantly shorten immobility time of mice in the forced swimming test, and dose-dependence significantly shorten immobility time of mice in the tail suspension test, after administration of 50, 100, and 200mg/kg, Chaihu Guizhi decoction, a significant dose-dependent antagonism of reserpine-induced hypothermia was observed in mice of each treatment group.
CONCLUSION
Chaihu Guizhi decoction has an antidepressant effect.
背景
柴胡桂枝汤具有治疗外感风寒、寒热往来、鼻鸣干呕、头痛剧烈、胸胁苦满等功效，在临床实践中，它还可用于治疗抑郁症。本文旨在研究柴胡桂枝汤的抗抑郁作用及其机制。
材料与方法
通过小鼠强迫游泳试验、悬尾试验及利血平拮抗试验研究柴胡桂枝汤的抗抑郁作用。
结果
柴胡桂枝汤能显著缩短小鼠强迫游泳试验中的不动时间，且在悬尾试验中能剂量依赖性地显著缩短小鼠的不动时间，给予50、100和200mg/kg柴胡桂枝汤后，各治疗组小鼠均出现了明显的剂量依赖性拮抗利血平所致体温降低的现象。
结论
柴胡桂枝汤具有抗抑郁作用。
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