[Antidepressant effect of water decoction of Rhizoma acori tatarinowii in the behavioural despair animal models of depression].

OBJECT

To assess the antidepressant effect of the water decoction of Rhizoma acori tatarinowii.

METHODS

By using the rat forced swimming test and mouse tail suspension test models of depression, the antidepressant effect of Rhizoma acori tatarinowii was observed.

RESULTS

The water decoction of Rhizoma acori tatarinowii and Fluoxetine significantly shortened motionless time of rat forced swimming and despair time of mouse tail suspension in the two behavioural despair animal models of depression. Antidepressant effect of water decoction of Rhizoma acori tatarinowii showed dose-dependence in the certain degree. The effect of water decoction of Rhizoma acori tatarinowii was weaker than that of Fluoxetine. There was a significant difference between every dose group of Rhizoma acori tatarinowii and saline control group.

CONCLUSION

The water decoction of Rhizoma acori tatarinowii possessed obviously antidepressant effect in the behavioural despair animal models of depression.