Wang Qing, Liu Yi-Hong, Xie Li, Hu Wen-Jing, Liu Bao-Rui
The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China.
Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu 210008, P.R. China.
Oncol Lett. 2015 Jan;9(1):91-95. doi: 10.3892/ol.2014.2668. Epub 2014 Nov 4.
The occurrence of cervical cancer during pregnancy is extremely rare, particularly small cell carcinoma. Small cell cervical carcinoma (SCCC) is a neuroendocrine tumor with a poor prognosis. This study presents the case of an 18-year-old female with stage IB2 SCCC complicated by pregnancy, who was treated with chemotherapy and radiotherapy. The patient was diagnosed shortly after giving birth, and is the youngest female case to be reported in the world. The patient was treated with cisplatin and etoposide chemotherapy and radiotherapy. Complete remission was achieved following neoadjuvant chemotherapy and radiotherapy, and the patient remains in clinical remission eight months following treatment. Cytological screening, colposcopy and if necessary, biopsy, and selective conization at 14-20 weeks should be considered in the patient evaluation.
妊娠期间发生宫颈癌极为罕见,尤其是小细胞癌。小细胞宫颈癌(SCCC)是一种预后较差的神经内分泌肿瘤。本研究报告了一例18岁IB2期SCCC合并妊娠的女性患者,该患者接受了化疗和放疗。患者在分娩后不久被确诊,是世界上报道的最年轻女性病例。患者接受了顺铂和依托泊苷化疗及放疗。新辅助化疗和放疗后实现了完全缓解,治疗后八个月患者仍处于临床缓解状态。在患者评估中应考虑进行细胞学筛查、阴道镜检查,必要时进行活检,以及在孕14 - 20周时进行选择性锥切术。