胃饥饿素可增加慢性常压缺氧状态下的淋巴细胞数量。
Ghrelin increases lymphocytes in chronic normobaric hypoxia.
作者信息
Mirzaie Bavil Fariba, Mohaddes Gisou, Ebrahimi Hadi, Keyhanmanesh Rana, Ghiyasi Rafigheh, Alipour Mohammad Reza
机构信息
Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Adv Pharm Bull. 2014 Dec;4(4):339-43. doi: 10.5681/apb.2014.049. Epub 2014 Aug 10.
PURPOSE
Hypoxia is a condition of decreased availability of oxygen. To adapt hypoxia, some changes in blood cells occur in the body. The aim of this study was to evaluate the effect of ghrelin on different types of blood cell in normobaric hypoxia situation.
METHODS
Thirty-two animals were divided in 4 groups (n=8): control (C), ghrelin (G), hypoxia (H), and hypoxic animals that received ghrelin (H+G). Hypoxia (11%) was induced by an Environmental Chamber System GO2 Altitude. Animals in ghrelin groups received a subcutaneous injection of ghrelin (150 μg/kg/day) for 14 days.
RESULTS
Our results show that ghrelin significantly (p<0.05) increased RBC and Hct levels, whereas it significantly (p<0.05) decreased lymphocytes in the blood. RBC, Hct, Hb concentration, platelet and MCV increased significantly (p<0.05) in hypoxic conditions but lymphocytes, monocytes and Polymorphonuclears did not show any significant changes. Platelets had a significant (p<0.05) decrease in hypoxic conditions and ghrelin administration in hypoxic conditions could increase lymphocyte levels significantly (p<0.05).
CONCLUSION
Effect of ghrelin on blood cells could be related to blood oxygen level. Ghrelin in normal oxygen conditions increases RBC and Hct levels but decreases lymphocytes, whereas in hypoxic conditions, ghrelin increases blood lymphocytes.
目的
缺氧是一种氧气供应减少的状态。为了适应缺氧，身体的血细胞会发生一些变化。本研究的目的是评估胃饥饿素在常压缺氧情况下对不同类型血细胞的影响。
方法
32只动物被分为4组（n = 8）：对照组（C）、胃饥饿素组（G）、缺氧组（H）以及接受胃饥饿素的缺氧动物组（H + G）。通过环境舱系统GO2海拔诱导11%的缺氧。胃饥饿素组的动物皮下注射胃饥饿素（150μg/kg/天），持续14天。
结果
我们的结果表明，胃饥饿素显著（p < 0.05）提高了红细胞和血细胞比容水平，而显著（p < 0.05）降低了血液中的淋巴细胞数量。在缺氧条件下，红细胞、血细胞比容、血红蛋白浓度、血小板和平均红细胞体积显著增加（p < 0.05），但淋巴细胞、单核细胞和多形核细胞没有显示出任何显著变化。血小板在缺氧条件下显著减少（p < 0.05），在缺氧条件下给予胃饥饿素可显著提高淋巴细胞水平（p < 0.05）。
结论
胃饥饿素对血细胞的影响可能与血氧水平有关。在正常氧气条件下，胃饥饿素会提高红细胞和血细胞比容水平，但会降低淋巴细胞数量，而在缺氧条件下，胃饥饿素会增加血液中的淋巴细胞。
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