Xu Jingjing, Wang Shuzhen, Lin Youting, Cao Lili, Wang Rong, Chi Zhaofu
Department of Neurology, Qilu Hospital, Shandong University, 44#, Wenhua Xi Road, Jinan 250012, PR China.
Neurosci Lett. 2009 Mar 27;453(1):58-61. doi: 10.1016/j.neulet.2009.01.067. Epub 2009 Jan 30.
Ghrelin, a 28-amino-acid peptide, is mainly secreted by the stomach. Evidence has shown ghrelin to have neuroprotective effects. However, whether ghrelin protects hippocampal neurons against cell death in pilocarpine-induced seizures is unknown. We used Nissl staining to show that ghrelin attenuated the neuronal loss caused by pilocarpine-induced seizures in the hippocampus. Ghrelin exerted the protective action through regulating the phosphatidylinositol-3-kinase and Akt pathway. Moreover, ghrelin treatment reversed the decreased ratio of Bcl-2 to Bax induced by seizures while inhibiting the activated caspase-3. Ghrelin can inhibit hippocampal neuronal damage caused by pilocarpine-induced seizures, which might have therapeutic value in seizures.
胃饥饿素是一种由28个氨基酸组成的肽，主要由胃分泌。有证据表明胃饥饿素具有神经保护作用。然而，胃饥饿素是否能保护海马神经元免受毛果芸香碱诱导的癫痫发作所致的细胞死亡尚不清楚。我们使用尼氏染色法显示，胃饥饿素减轻了毛果芸香碱诱导的癫痫发作在海马体中引起的神经元损失。胃饥饿素通过调节磷脂酰肌醇-3-激酶和Akt信号通路发挥保护作用。此外，胃饥饿素治疗逆转了癫痫发作诱导的Bcl-2与Bax比值的降低，同时抑制了活化的半胱天冬酶-3。胃饥饿素可以抑制毛果芸香碱诱导的癫痫发作所导致的海马神经元损伤，这可能对癫痫具有治疗价值。
