肝动脉灌注化疗可减少胰腺癌胰十二指肠切除术后的肝转移。

Hepatic arterial infusion chemotherapy reduced hepatic metastases from pancreatic cancer after pancreatectomy.

作者信息

Zheng Yin Yuan, Tang Cheng Wu, Xu Yong Qiang, Feng Wen Ming, Bao Ying, Fei Mao Yun

出版信息

Hepatogastroenterology. 2014 Jul-Aug;61(133):1415-20.

Abstract

BACKGROUND/AIMS: This study aims to investigate the safety and efficacy of hepatic arterial infusion chemotherapy (HAIC) on liver metastases from pancreatic cancer after pancreatectomy.

METHODOLOGY

We randomly assigned 106 patients with pancreatic cancer after pancreatectomy between 2005 and 2010 to receive 2 cycles of HAIC plus 4 cycles of systemic chemotherapy (Combined Therapy) or 6 cycles of systemic chemotherapy alone (Monotherapy). Both the HAIC and systemic chemotherapy regimen consisted of a 5-hour infusion of 5-fluorouracil 1000 mg/m2 on day 1 followed by gemcitabine 800 mg/m2 as an over 30-min infusion on day 1 and day 8. The treatment was started on an average of 21.2 days after surgery and repeated every 4 weeks. The disease-free survival, overall survival and liver metastases-free survival were compared.

RESULTS

There was no significant difference in adverse effects between two groups. Significant differences were found in 3-year overall survival (Combined Therapy, 23.08 %; Monotherapy, 14.81%; P=0.0473) and liver metastases-free survival (Combined Therapy, 80.77%; Monotherapy, 55.56%; P=0.0014).

CONCLUSIONS

HAIC effectively and safely prevents liver metastases and improves the prognosis of patients with pancreatic cancer after pancreatectomy.

摘要

背景/目的：本研究旨在探讨肝动脉灌注化疗（HAIC）对胰腺癌切除术后肝转移的安全性和有效性。

方法

我们将2005年至2010年间106例胰腺癌切除术后患者随机分为两组，一组接受2个周期的HAIC加4个周期的全身化疗（联合治疗组），另一组仅接受6个周期的全身化疗（单一治疗组）。HAIC和全身化疗方案均为第1天5-氟尿嘧啶1000mg/m²持续静脉输注5小时，随后第1天和第8天吉西他滨800mg/m²静脉输注超过30分钟。治疗平均在术后21.2天开始，每4周重复一次。比较两组的无病生存期、总生存期和无肝转移生存期。