Hagiwara Ken, Kochi Mitsugu, Fujii Masashi, Song Keio, Tamegai Hidenori, Watanabe Megumu, Takayama Yuriko, Suda Hiroshi, Teshima Youichi, Takayama Tadatoshi
Hepatogastroenterology. 2014 Sep;61(134):1617-22.
BACKGROUND/AIMS: The goal of this retrospective study was to investigate the efficacy and safety of curative radiochemotherapy (CRT) in elderly patients with esophageal squamous cell cancer (SCC).
Between 1986 and 2011, 38 consecutive patients aged over 75 years with esophageal SCC were initially treated with a CRT regimen comprising radiation therapy at a dose of 60 Gy and two cycles of chemotherapy with 5-fluorouracil/cisplatin.
Fourteen patients were aged over 80 and 24 under 79 years. Complete treatment compliance was obtained in 30 (78.9%) of the patients. Chemotherapy was terminated and the dose of radiation reduced in 7 and 1 patients, respectively. The overall incidence of CRT-related complications was 86.8% (33 patients). Grade 3 leukocytopenia was observed in 6 (15.8%) patients, all of whom recovered promptly. A complete response was observed in 17 patients (44.7%). The overall 3-year survival rate was 32.0%.
Curative CRT is safe and may improve overall and progression-free 3-year survival rates in elderly patients aged more than 75 years with esophageal SCC.
背景/目的：本回顾性研究旨在探讨根治性放化疗（CRT）在老年食管鳞状细胞癌（SCC）患者中的疗效和安全性。
1986年至2011年间，38例年龄超过75岁的食管SCC患者最初接受了CRT方案治疗，该方案包括60 Gy的放射治疗以及两个周期的5-氟尿嘧啶/顺铂化疗。
14例患者年龄超过80岁，24例年龄在79岁以下。30例（78.9%）患者完成了全部治疗。分别有7例和1例患者终止化疗并减少了放射剂量。CRT相关并发症的总发生率为86.8%（33例患者）。6例（15.8%）患者出现3级白细胞减少，所有患者均迅速康复。17例患者（44.7%）观察到完全缓解。3年总生存率为32.0%。
根治性CRT是安全的，可能会提高75岁以上老年食管SCC患者的3年总生存率和无进展生存率。
