Inoue Jun, Sato Ryuichiro
Biomol Concepts. 2013 Aug;4(4):417-23. doi: 10.1515/bmc-2013-0009.
Abstract Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate a wide variety of genes involved in cholesterol and fatty acid synthesis. After transcription, SREBPs are controlled at multiple post-transcriptional levels, including proteolytic processing and post-translational modification. Among these, proteolytic processing is a crucial regulatory step that activates SREBPs, which are synthesized as inactive endoplasmic reticulum membrane proteins. In this review, we focus on recent progress with regard to signaling pathways and small molecules that affect activation of SREBPs by proteolytic processing.
摘要 固醇调节元件结合蛋白（SREBPs）是一类转录因子，可调节多种参与胆固醇和脂肪酸合成的基因。转录后，SREBPs在多个转录后水平受到调控，包括蛋白水解加工和翻译后修饰。其中，蛋白水解加工是激活SREBPs的关键调控步骤，SREBPs最初作为无活性的内质网膜蛋白合成。在本综述中，我们重点关注影响SREBPs通过蛋白水解加工激活的信号通路和小分子的最新进展。
