Cortés-Prieto Joaquín, Vicente-Hernanz Maria Lina, Cortés-García Ana, Keller Jerry, del Rio Rosario Cintas, Brita-Paja Segoviano José Luis
Gynecology Department of Medical Specialities, Medical School, University of Alcala, Alcala, Spain.
Horm Mol Biol Clin Investig. 2013 Jun;13(2):19-40. doi: 10.1515/hmbci-2013-0002.
One hundred and eighty-five female never-hormone users with a mean age of 50.71 (SD = 5.58) years upon initiation of treatment were studied before instauration and during treatment. The profile of patients subjected to the study included body mass index (BMI), bone mineral density (BMD), and lipid profile (LP). In our population, pretreatment values were within the normal range, which is why a hormone replacement therapy (HRT), conjugated equine estrogen plus medroxyprogesterone acetate, was administered to a healthy population of women for 9.82 ± 5.42 years and follow-up comprised 1815.84 woman-years. To study the effects of treatment on the investigated clinical subjects, we resorted to comparative analyses of pretreatment and posttreatment mean values: descriptive and comparative hypothesis, followed by a repeated measurements design to investigate the evolution on three levels according to age groups just before the initiation of the treatment and on the other three levels during the treatment with a minimum follow-up of 9 years. On the basis of the numerical results, we were able to conclude that BMD decreased significantly (p = 0.00) well above the values found on curves corresponding to these age groups. The total cholesterol decreased significantly at 2-3 years interval (p = 0.04). The rest of the LP factors remained within a safe margin. Therefore, long-term HRT may be considered initially as a beneficial alternative in the treated study population.
185名开始治疗时平均年龄为50.71（标准差=5.58）岁的从未使用过激素的女性在治疗开始前和治疗期间接受了研究。接受研究的患者资料包括体重指数（BMI）、骨密度（BMD）和血脂谱（LP）。在我们的研究人群中，治疗前的值在正常范围内，这就是为什么对健康女性人群给予激素替代疗法（HRT），即结合马雌激素加醋酸甲羟孕酮，为期9.82±5.42年，随访时间为1815.84女性年。为了研究治疗对所研究临床指标的影响，我们对治疗前和治疗后的平均值进行了比较分析：描述性和比较性假设，然后采用重复测量设计，根据治疗开始前的年龄组在三个水平上以及在治疗期间的另外三个水平上进行研究，最短随访时间为9年。根据数值结果，我们能够得出结论，骨密度显著降低（p=0.00），远高于这些年龄组曲线对应的数值。总胆固醇在2至3年的间隔内显著降低（p=0.04）。其余的血脂谱因素保持在安全范围内。因此，在接受治疗的研究人群中，长期激素替代疗法最初可被视为一种有益的选择。
