Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada.
Pathogens. 2012 Oct 24;1(2):128-55. doi: 10.3390/pathogens1020128.
Salmonella spp. are a leading cause of human infectious disease worldwide and pose a serious health concern. While we have an improving understanding of pathogenesis and the host-pathogen interactions underlying the infection process, comparatively little is known about the survival of pathogenic Salmonella outside their hosts. This review focuses on three areas: (1) in vitro evidence that Salmonella spp. can survive for long periods of time under harsh conditions; (2) observations and conclusions about Salmonella persistence obtained from human outbreaks; and (3) new information revealed by genomic- and population-based studies of Salmonella and related enteric pathogens. We highlight the mechanisms of Salmonella persistence and transmission as an essential part of their lifecycle and a prerequisite for their evolutionary success as human pathogens.
沙门氏菌属是全球人类传染病的主要原因，对人类健康构成严重威胁。尽管我们对发病机制和感染过程中宿主-病原体相互作用的理解在不断提高，但对于病原性沙门氏菌在宿主外的存活情况却知之甚少。本综述集中讨论了三个方面：（1）体外证据表明，沙门氏菌属可以在恶劣条件下长时间存活；（2）从人类疫情中观察到的和得出的关于沙门氏菌持续存在的结论；（3）通过对沙门氏菌和相关肠道病原体进行基因组和基于种群的研究揭示的新信息。我们强调了沙门氏菌持续存在和传播的机制，这是其生命周期的重要组成部分，也是其作为人类病原体进化成功的先决条件。
