*Radiotherapy Related Research, The Christie NHS Foundation Trust and University of Manchester, Manchester, United Kingdom; †Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, United Kingdom; and ‡Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.
J Thorac Oncol. 2014 Nov;9(11):1598-608. doi: 10.1097/JTO.0000000000000346.
Radiotherapy plays an important role in the management of lung cancer, with over 50% of patients receiving this modality at some point during their treatment. Intensity-modulated radiotherapy (IMRT) is a technique that adds fluence modulation to beam shaping, which improves radiotherapy dose conformity around the tumor and spares surrounding normal structures. Treatment with IMRT is becoming more widely available for the treatment of lung cancer, despite the paucity of high level evidence supporting the routine use of this more resource intense and complex technique. In this review article, we have summarized data from planning and clinical studies, discussed challenges in implementing IMRT, and made recommendations on the minimum requirements for safe delivery of IMRT.
放疗在肺癌的治疗中起着重要作用，超过 50%的患者在治疗过程中的某个阶段接受这种治疗方式。调强放疗（IMRT）是一种在射束成型中增加剂量调制的技术，可提高肿瘤周围的放疗剂量一致性，并保护周围正常组织。尽管缺乏高水平证据支持常规使用这种资源密集型和复杂的技术，但使用 IMRT 治疗肺癌的方法越来越普及。在这篇综述文章中，我们总结了来自计划和临床研究的数据，讨论了实施 IMRT 的挑战，并就安全实施 IMRT 的最低要求提出了建议。
