Escalada Francisco Javier
Departamento de Endocrinología y Nutrición, Clínica Universidad de Navarra, Facultad de Medicina, Universidad de Navarra, Pamplona, España.
Med Clin (Barc). 2014 Sep;143 Suppl 2:2-7. doi: 10.1016/S0025-7753(14)70101-0. Epub 2014 Oct 15.
The hormone glucagon-like peptide-1 (GLP-1) is synthesized and secreted by L cells in the small intestine in response to food ingestion. After reaching the general circulation it has a half-life of 2-3 minutes due to degradation by the enzyme dipeptidyl peptidase-4. Its physiological role is directed to control plasma glucose concentration, though GLP-1 also plays other different metabolic functions following nutrient absorption. Biological activities of GLP-1 include stimulation of insulin biosynthesis and glucose-dependent insulin secretion by pancreatic beta cell, inhibition of glucagon secretion, delay of gastric emptying and inhibition of food intake. GLP-1 is able to reduce plasma glucose levels in patients with type 2 diabetes and also can restore beta cell sensitivity to exogenous secretagogues, suggesting that the increasing GLP-1 concentration may be an useful therapeutic strategy for the treatment of patients with type 2 diabetes.
胰高血糖素样肽-1（GLP-1）是一种激素，由小肠中的L细胞在摄入食物后合成并分泌。进入体循环后，由于被二肽基肽酶-4降解，其半衰期为2至3分钟。其生理作用旨在控制血糖浓度，不过GLP-1在营养物质吸收后也发挥其他不同的代谢功能。GLP-1的生物学活性包括刺激胰岛β细胞的胰岛素生物合成和葡萄糖依赖性胰岛素分泌、抑制胰高血糖素分泌、延缓胃排空以及抑制食物摄入。GLP-1能够降低2型糖尿病患者的血糖水平，还可恢复β细胞对外源促分泌剂的敏感性，这表明提高GLP-1浓度可能是治疗2型糖尿病患者的一种有效治疗策略。
