探索 iNKT 细胞在抗乙肝治疗中的治疗潜力。
Exploring the Therapeutic Potentials of iNKT Cells for Anti-HBV Treatment.
机构信息
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
出版信息
Pathogens. 2014 Jul 3;3(3):563-76. doi: 10.3390/pathogens3030563.
CD1d-restricted invariant NKT (iNKT) cells are a group of innate-like regulatory T cells that recognize lipid antigens. Both mouse modeling experiments and human clinical studies have suggested a key role for iNKT cells in anti-HBV immunity and these potent T cells can be explored as a novel therapeutic target for anti-HBV treatment. We aim to humanize mice in the CD1d/iNKT cell lipid presentation system and provide new research tools for identifying novel anti-HBV agents.
CD1d 限制性不变自然杀伤 T(iNKT)细胞是一群识别脂质抗原的固有样调节性 T 细胞。小鼠模型实验和人类临床研究均表明 iNKT 细胞在抗乙型肝炎病毒(HBV)免疫中起关键作用，这些强效 T 细胞可作为抗 HBV 治疗的新的治疗靶点进行探索。本研究旨在人源化 CD1d/iNKT 细胞脂质呈递系统中的小鼠，为鉴定新型抗 HBV 药物提供新的研究工具。
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