Department of Biology and Sbarro Health Research Organization, College of Science and Technology, Temple University, 1900 N. 12th Street, Philadelphia, Pennsylvania 19122, USA.
Nat Rev Cancer. 2013 Feb;13(2):123-35. doi: 10.1038/nrc3449.
Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C virus (HCV) infections. There are few effective treatments partly because the cell- and molecular-based mechanisms that contribute to the pathogenesis of this tumour type are poorly understood. This Review outlines pathogenic mechanisms that seem to be common to both viruses and which suggest innovative approaches to the prevention and treatment of HCC.
肝细胞癌 (HCC) 是一种高致死性癌症，全球发病率不断上升，主要与慢性乙型肝炎病毒 (HBV) 和/或丙型肝炎病毒 (HCV) 感染有关。由于导致这种肿瘤类型发病的细胞和分子机制尚未完全清楚，因此治疗方法有限。本文综述了似乎两种病毒共有的发病机制，并提出了预防和治疗 HCC 的创新方法。
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