van Dongen Marijn N, Serdijn Wouter A
IEEE Trans Biomed Circuits Syst. 2016 Feb;10(1):61-71. doi: 10.1109/TBCAS.2014.2363736. Epub 2014 Nov 24.
This paper presents a neural stimulator system that employs a fundamentally different way of stimulating neural tissue compared to classical constant current stimulation. A stimulation pulse is composed of a sequence of current pulses injected at a frequency of 1 MHz for which the duty cycle is used to control the stimulation intensity. The system features 8 independent channels that connect to any of the 16 electrodes at the output. A sophisticated control system allows for individual control of each channel's stimulation and timing parameters. This flexibility makes the system suitable for complex electrode configurations and current steering applications. Simultaneous multichannel stimulation is implemented using a high frequency alternating technique, which reduces the amount of electrode switches by a factor 8. The system has the advantage of requiring a single inductor as its only external component. Furthermore it offers a high power efficiency, which is nearly independent on both the voltage over the load as well as on the number of simultaneously operated channels. Measurements confirm this: in multichannel mode the power efficiency can be increased for specific cases to 40% compared to 20% that is achieved by state-of-the-art classical constant current stimulators with adaptive power supply.
本文介绍了一种神经刺激器系统,与传统的恒流刺激相比,它采用了一种根本不同的方式来刺激神经组织。一个刺激脉冲由一系列以1MHz频率注入的电流脉冲组成,其占空比用于控制刺激强度。该系统具有8个独立通道,可连接到输出端的16个电极中的任何一个。一个复杂的控制系统允许对每个通道的刺激和定时参数进行单独控制。这种灵活性使该系统适用于复杂的电极配置和电流转向应用。同时多通道刺激采用高频交替技术实现,可将电极开关数量减少8倍。该系统的优点是仅需一个电感作为其唯一的外部组件。此外,它具有高功率效率,几乎与负载两端的电压以及同时工作的通道数量无关。测量结果证实了这一点:在多通道模式下,对于特定情况,功率效率可提高到40%,而采用自适应电源的最先进传统恒流刺激器的功率效率为20%。