Patil Pallavi, Shah Vinaya, Shah Bipin
J Assoc Physicians India. 2014 May;62(5):406-10.
The objective of our study was to evaluate and standardise the method of spot (random) urine protein creatinine ratio (UP/C) for estimation of proteinuria. The study contained 241 study participants in a tertiary care hospital inclusive of 208 cases and 33 normal volunteers. The 24 hour urine protein estimation was done on 24 hour urine samples and UP/C ratio was calculated on random urine samples. UP/C ratio and 24 hour urine protein estimation had strong correlation with r = 0.9 and p < 0.05 on Pearson's correlation analysis. Receiver operating characteristic analysis showed random UP/C ratio of 0.1171 reliably predicted 24 hour urine total protein equivalent of > 150 mg/24 hrs with sensitivity 100%, specificity 98.1%, positive likelihood ratio 53.5, and negative likelihood ratio 0. UP/C ratio of 3.2 reliably predicted nephrotic range proteinuria at 24 hour urine protein equivalent of > 3.5 g/24 hrs with sensitivity 80%, specificity 100%, positive likelihood ratio 154.4, and negative likelihood ratio 0.2. We conclude that spot/random UP/C ratio is a reliable, simple test to be introduced and adopted in routine practice for monitoring of macro proteinuria.
我们研究的目的是评估并标准化用于估计蛋白尿的随机尿蛋白肌酐比值（UP/C）方法。该研究纳入了一家三级护理医院的241名研究参与者，包括208例患者和33名正常志愿者。对24小时尿液样本进行24小时尿蛋白测定，并对随机尿液样本计算UP/C比值。经Pearson相关性分析，UP/C比值与24小时尿蛋白测定具有强相关性，r = 0.9且p < 0.05。受试者工作特征分析显示，随机UP/C比值为0.1171时可可靠预测24小时尿总蛋白当量>150 mg/24小时，敏感性为100%，特异性为98.1%，阳性似然比为53.5，阴性似然比为0。UP/C比值为3.2时可可靠预测24小时尿蛋白当量>3.5 g/24小时的肾病范围蛋白尿，敏感性为80%，特异性为100%得，阳性似然比为154.4，阴性似然比为0.2。我们得出结论，随机/即时UP/C比值是一种可靠、简便的检测方法，可引入并应用于常规实践中以监测大量蛋白尿。
