Described the real pyramidal and extrapyramidal neural networks of the mammalian brain, realizing asbehavior, motor control and involved in learning and memory. The algorithm of postsynaptic excitatory glutamatergic synapses plasticity analyzed, which leads to the modification and storage for a long time, the efficiency of synaptic transmission --ong-term potentiation, long-term depression. Analyzed the mechanisms of plasticity allosteric GABAA(-)redcptors. Described the molecular and cellular mechanisms of the trafficking of GABAA(-)receptors and its role in the dynamic modulation of neuronal inhibition. Analyzed molecular and cellular plasticity algorithm of allosteric GABAA(-)receptors. Discussed hypoth-sis update neural networks that is realized on a molecular level with the internalization and recycling mechanism specific GABAA(-)receptor cluster. It is assumed that the process of transfer from the memory stage storage to the stage of working memory. Deactualization of neural network, which is implemented at the molecular level by the mechanism of internalization specific cluster of GABAA(-)receptor, is a pro-ess of transferring from stage of working or random access memory in the storage stage.