Walsh Eamonn, Oakley David A, Halligan Peter W, Mehta Mitul A, Deeley Quinton
Cultural and Social Neuroscience Research Group, Forensic and Neurodevelopmental Sciences, Kings College London, Institute of Psychiatry, Psychology & Neuroscience, London, UK; Department of Psychological Sciences, Birkbeck, University of London, London, UK.
Division of Psychology and Language Sciences, University College London, UK.
Cortex. 2015 Mar;64:380-93. doi: 10.1016/j.cortex.2014.09.012. Epub 2014 Oct 5.
Alien control phenomena are symptoms reported by patients with schizophrenia whereby feelings of control and ownership of thoughts and movements are lost. Comparable alien control experiences occur in culturally influenced dissociative states. We used fMRI and suggestions for automatic writing in highly hypnotically suggestible individuals to investigate the neural underpinnings of alien control. Targeted suggestions selectively reduced subjective ratings of control and ownership for both thought and movement. Thought insertion (TI) was associated with reduced activation of networks supporting language, movement, and self-related processing. In contrast, alien control of writing movement was associated with increased activity of a left-lateralised cerebellar-parietal network and decreased activity in brain regions involved in voluntary movement, including sensory-motor hand areas and the thalamus. Both experiences involved a reduction in activity of left supplementary motor area (SMA) and were associated with altered functional connectivity (FC) between SMA and brain regions involved in language processing and movement implementation. Collectively these results indicate the SMA plays a central role in alien control phenomena as a high level executive system involved in the sense that we control and own our thoughts and movements.
被控制感现象是精神分裂症患者报告的症状，即失去对思想和行动的控制感及自主感。在受文化影响的分离状态中也会出现类似的被控制体验。我们利用功能磁共振成像（fMRI）以及对高度易被催眠个体进行自动书写的暗示，来探究被控制感的神经基础。针对性的暗示选择性地降低了对思想和行动的控制感及自主感的主观评分。思维插入（TI）与支持语言、运动和自我相关加工的神经网络激活减少有关。相比之下，书写动作的被控制感与左侧小脑 - 顶叶网络活动增加以及参与自主运动的脑区活动减少有关，包括感觉运动手部区域和丘脑。这两种体验都涉及左侧辅助运动区（SMA）活动减少，并且与SMA和参与语言加工及运动执行的脑区之间功能连接（FC）改变有关。总体而言，这些结果表明SMA在被控制感现象中起着核心作用，作为一个高级执行系统参与到我们对思想和行动的控制及自主感之中。
