黑色素瘤脑转移患者的全脑放疗
Whole-brain radiotherapy in patients with brain metastases from melanoma.
作者信息
de la Fuente Macarena, Beal Kathryn, Carvajal Richard, Kaley Thomas J
机构信息
Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
出版信息
CNS Oncol. 2014 Nov;3(6):401-6. doi: 10.2217/cns.14.40.
Abstract
AIMS
To describe results of melanoma brain metastases (BM) treated with whole-brain radiation (WBRT).
METHODS
Retrospective review of patients with melanoma BM treated with WBRT divided into two groups based on the timing of WBRT (at BM diagnosis or recurrence).
RESULTS
We identified 61 patients with melanoma BM who received WBRT. For the group treated at diagnosis (n = 39): median overall survival was 3 months; best radiographic response included one partial response, ten stable disease, 18 progressive disease, and ten no follow-up imaging. For the group treated at recurrence (n = 22): median overall survival was 3 months; best radiographic response was three partial response, four stable disease, eight progressive disease, and seven no follow-up imaging.
CONCLUSION
WBRT activity was limited; however, its role in symptom palliation is unclear.
摘要
目的
描述采用全脑放疗（WBRT）治疗黑色素瘤脑转移（BM）的结果。
方法
对接受WBRT治疗的黑色素瘤BM患者进行回顾性分析，根据WBRT的时间（BM诊断时或复发时）分为两组。
结果
我们确定了61例接受WBRT治疗的黑色素瘤BM患者。诊断时治疗组（n = 39）：中位总生存期为3个月；最佳影像学反应包括1例部分缓解、10例疾病稳定、18例疾病进展和10例未进行后续影像学检查。复发时治疗组（n = 22）：中位总生存期为3个月；最佳影像学反应为3例部分缓解、4例疾病稳定、8例疾病进展和7例未进行后续影像学检查。
结论
WBRT的活性有限；然而，其在缓解症状方面的作用尚不清楚。
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