Cohen Justine V, Tawbi Hussain, Margolin Kim A, Amravadi Ravi, Bosenberg Marcus, Brastianos Priscilla K, Chiang Veronica L, de Groot John, Glitza Isabella C, Herlyn Meenhard, Holmen Sheri L, Jilaveanu Lucia B, Lassman Andrew, Moschos Stergios, Postow Michael A, Thomas Reena, Tsiouris John A, Wen Patrick, White Richard M, Turnham Timothy, Davies Michael A, Kluger Harriet M
Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.
Department of Melanoma, Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Pigment Cell Melanoma Res. 2016 Nov;29(6):627-642. doi: 10.1111/pcmr.12538. Epub 2016 Oct 22.
Melanoma central nervous system metastases are increasing, and the challenges presented by this patient population remain complex. In December 2015, the Melanoma Research Foundation and the Wistar Institute hosted the First Summit on Melanoma Central Nervous System (CNS) Metastases in Philadelphia, Pennsylvania. Here, we provide a review of the current status of the field of melanoma brain metastasis research; identify key challenges and opportunities for improving the outcomes in patients with melanoma brain metastases; and set a framework to optimize future research in this critical area.
黑色素瘤中枢神经系统转移的情况日益增多，这一患者群体所带来的挑战依然复杂。2015年12月，黑色素瘤研究基金会和维斯达研究所于宾夕法尼亚州费城主办了首届黑色素瘤中枢神经系统转移峰会。在此，我们对黑色素瘤脑转移研究领域的现状进行综述；确定改善黑色素瘤脑转移患者治疗结果的关键挑战和机遇；并建立一个框架以优化这一关键领域的未来研究。
