Palta Priya, Golden Sherita H, Teresi Jeanne, Palmas Walter, Weinstock Ruth S, Shea Steven, Manly Jennifer J, Luchsinger Jose A
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
J Am Geriatr Soc. 2014 Dec;62(12):2363-8. doi: 10.1111/jgs.13129. Epub 2014 Nov 29.
To determine whether older adults with type 2 diabetes mellitus and cognitive dysfunction have poorer metabolic control of glycosylated hemoglobin, systolic blood pressure, and low-density lipoprotein cholesterol than those without cognitive dysfunction.
Prospective cohort study.
A minority cohort in New York City previously recruited for a trial of telemedicine.
Persons aged 73.0 ± 3.0 (N = 613; 69.5% female; 82.5% Hispanic, 15.5% non-Hispanic black).
Participants were classified with executive or memory dysfunction based on standardized score cutoffs (<16th percentile) for the Color Trails Test and Selective Reminding Test. Linear mixed models were used to compare repeated measures of the metabolic measures and evaluate the rates of change in individuals with and without dysfunction.
Of the 613 participants, 331 (54%) had executive dysfunction, 202 (33%) had memory dysfunction, and 96 (16%) had both. Over a median of 2 years, participants with executive or memory dysfunction did not exhibit significantly poorer metabolic control than those without executive function or memory type cognitive dysfunction.
Cognitive dysfunction in the mild range did not seem to affect diabetes mellitus control parameters in this multiethnic cohort of older adults with diabetes mellitus, although it cannot be excluded that cognitive impairment was overcome through assistance from formal or informal caregivers. It is possible that more-severe cognitive dysfunction could affect control.
确定患有2型糖尿病和认知功能障碍的老年人在糖化血红蛋白、收缩压和低密度脂蛋白胆固醇的代谢控制方面是否比没有认知功能障碍的老年人更差。
前瞻性队列研究。
纽约市一个先前招募用于远程医疗试验的少数族裔队列。
年龄73.0±3.0岁(N = 613;69.5%为女性;82.5%为西班牙裔,15.5%为非西班牙裔黑人)。
根据色线试验和选择性提醒试验的标准化分数临界值(<第16百分位数)将参与者分类为执行功能或记忆功能障碍。使用线性混合模型比较代谢指标的重复测量值,并评估有无功能障碍个体的变化率。
在613名参与者中,331名(54%)有执行功能障碍,202名(33%)有记忆功能障碍,96名(16%)两者都有。在中位数为2年的时间里,有执行功能或记忆功能障碍的参与者在代谢控制方面并不比没有执行功能或记忆型认知功能障碍的参与者明显更差。
在这个患有糖尿病的多民族老年人群体中,轻度认知功能障碍似乎并未影响糖尿病控制参数,尽管不能排除通过正式或非正式护理人员的帮助克服了认知障碍。更严重的认知功能障碍有可能影响控制情况。