Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool Women's Hospital, Liverpool, UK.
Acta Physiol (Oxf). 2015 Feb;213(2):417-31. doi: 10.1111/apha.12431. Epub 2014 Dec 23.
In this review, we give a state-of-the-art account of uterine contractility, focussing on excitation-contraction (electro-mechanical) coupling (ECC). This will show how electrophysiological data and intracellular calcium measurements can be related to more modern techniques such as confocal microscopy and molecular biology, to advance our understanding of mechanical output and its modulation in the smooth muscle of the uterus, the myometrium. This new knowledge and understanding, for example concerning the role of the sarcoplasmic reticulum (SR), or stretch-activated K channels, when linked to biochemical and molecular pathways, provides a clearer and better informed basis for the development of new drugs and targets. These are urgently needed to combat dysfunctions in excitation-contraction coupling that are clinically challenging, such as preterm labour, slow to progress labours and post-partum haemorrhage. It remains the case that scientific progress still needs to be made in areas such as pacemaking and understanding interactions between the uterine environment and ion channel activity.
在这篇综述中，我们介绍了子宫收缩性的最新研究进展，重点介绍了兴奋-收缩（电机械）偶联（ECC）。这将展示如何将电生理数据和细胞内钙测量与共聚焦显微镜和分子生物学等现代技术相关联，以增进我们对子宫平滑肌（子宫肌层）机械输出及其调制的理解。这种新知识和理解，例如关于肌浆网（SR）或伸展激活的 K 通道的作用，当与生化和分子途径相关联时，为开发新的药物和靶点提供了更清晰、更明智的基础。这些都是对抗临床上具有挑战性的兴奋-收缩偶联功能障碍（如早产、进展缓慢的分娩和产后出血）所急需的。在起搏和理解子宫环境与离子通道活性之间的相互作用等方面，科学仍需取得进展。
