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小脑在精神疾病神经生物学中的作用。

The role of the cerebellum in neurobiology of psychiatric disorders.

作者信息

Shakiba Alia

机构信息

Department of Psychiatry, Tehran University of Medical Sciences, Rouzbeh Hospital, 606 South Kargar Avenue, Tehran 1333795914, Iran.

出版信息

Neurol Clin. 2014 Nov;32(4):1105-15. doi: 10.1016/j.ncl.2014.07.008. Epub 2014 Sep 11.

Abstract

For a long time, cerebellum was only known for its role in movement coordination and until recently, its role in non-motor brain function was largely ignored. Recent evidences has expanded the concept of coordination, from voluntary movements and orientation of the body to nearly every cerebral function including emotion regulation, social cognition, and time perception. This article aims to review the current evidences supporting the role of the cerebellum in the pathophysiology of psychiatric disorders, including studies using volumetric and/or functional imaging techniques, genetic and molecular studies, and clinical reports. The implication of these findings, their potential use, and future directions are also discussed.

摘要

长期以来,小脑仅因其在运动协调中的作用为人所知,直到最近,其在非运动脑功能中的作用在很大程度上被忽视。最近的证据扩展了协调的概念,从自主运动和身体定向扩展到几乎每一项脑功能,包括情绪调节、社会认知和时间感知。本文旨在综述支持小脑在精神疾病病理生理学中作用的当前证据,包括使用体积和/或功能成像技术的研究、遗传和分子研究以及临床报告。还讨论了这些发现的意义、潜在用途和未来方向。

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