National Clinical Research Center for Mental Disorders, Department of Psychaitry, China National Technology Institute on Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
The Second Xiangya Hospital of Central South University, Changsha, China.
Brain Behav. 2021 May;11(5):e02117. doi: 10.1002/brb3.2117. Epub 2021 Mar 26.
Previous positron emission tomography studies have reported the changes of cerebral glucose metabolism in bipolar disorder. However, the findings across studies remain controversial, containing differing results.
A systematic literature search of the PubMed, Embase, Cochrane Library, and Web of Science databases was conducted. We conducted a voxel-wide meta-analysis of cerebral glucose metabolism studies, using the seed-based mapping approach, in patients with bipolar disorder (BD).
We identified 7 studies suitable for inclusion, which included a total of 126 individuals with BD and 160 healthy controls. The most consistent and robust findings were an increase in cerebral glucose metabolism in the right precentral gyrus and a decrease in the left superior temporal gyrus, left middle temporal gyrus, and cerebellum. Additionally, the sex distribution and illness duration had significant moderating effects on cerebral glucose metabolism alterations.
Cerebral glucose metabolism alterations in these brain regions are likely to reflect the disease-related functional abnormalities such as emotion and cognition. These findings contribute to a better understanding of the neurobiological underpinnings of bipolar disorder.
This study was done at a study level and cannot be addressed at the patient level. Subgroup analysis of BD I and BD II is not possible due to limited literature data.
先前的正电子发射断层扫描研究报告了双相情感障碍患者大脑葡萄糖代谢的变化。然而，研究结果仍存在争议，包含不同的结果。
我们对 PubMed、Embase、Cochrane 图书馆和 Web of Science 数据库进行了系统的文献检索。我们采用基于种子的映射方法，对双相情感障碍患者的大脑葡萄糖代谢研究进行了体素级别的荟萃分析。
我们确定了 7 项适合纳入的研究，共纳入了 126 名双相情感障碍患者和 160 名健康对照者。最一致和最有力的发现是右侧中央前回的大脑葡萄糖代谢增加，以及左侧颞上回、左侧颞中回和小脑的减少。此外，性别分布和疾病持续时间对大脑葡萄糖代谢变化有显著的调节作用。
这些脑区的大脑葡萄糖代谢变化可能反映了与疾病相关的功能异常，如情绪和认知。这些发现有助于更好地理解双相情感障碍的神经生物学基础。
本研究是在研究水平上进行的，不能在患者水平上解决。由于文献数据有限，无法对 BD I 和 BD II 进行亚组分析。
