参与钠通道激活和失活的结构部分。

Structural parts involved in activation and inactivation of the sodium channel.

作者信息

Stühmer W, Conti F, Suzuki H, Wang X D, Noda M, Yahagi N, Kubo H, Numa S

机构信息

Max-Planck-Institut für biophysikalische Chemie, Göttingen, FRG.

出版信息

Nature. 1989 Jun 22;339(6226):597-603. doi: 10.1038/339597a0.

DOI:10.1038/339597a0

PMID:2543931

Abstract

Structure-function relationships of the sodium channel expressed in Xenopus oocytes have been investigated by the combined use of site-directed mutagenesis and patch-clamp recording. This study provides evidence that the positive charges in segment S4 are involved in the voltage-sensing mechanism for activation of the channel and that the region between repeats III and IV is important for its inactivation.

摘要

通过结合使用定点诱变和膜片钳记录技术，对非洲爪蟾卵母细胞中表达的钠通道的结构-功能关系进行了研究。这项研究提供了证据，表明S4片段中的正电荷参与了通道激活的电压传感机制，并且重复序列III和IV之间的区域对其失活很重要。