Franzone Anna, Stabile Eugenio, Trimarco Bruno, Esposito Giovanni
Division of Cardiology, Department of Advanced Biomedical Sciences, University of Napoli "Federico II", Via S. Pansini 5, Napoli 80131, Italy.
Division of Cardiology, Department of Advanced Biomedical Sciences, University of Napoli "Federico II", Via S. Pansini 5, Napoli 80131, Italy.
Cardiol Clin. 2015 Feb;33(1):151-62. doi: 10.1016/j.ccl.2014.09.005.
This article reviews current knowledge and applications of drug-eluting devices in the treatment of peripheral arterial disease. The authors briefly report on the performance of plain old balloon angioplasty and bare metal stents in femoro-popliteal and below-the-knee lesions. This article explains the rationale behind the development of drug-eluting devices and describes the main technical features of currently available drug-eluting stents and drug-coated balloons. Dedicated sections discuss the results of trials investigating the potential benefits of these devices used in femoro-popliteal and infra-popliteal arterial vascular beds. Finally, ongoing studies and potential novel applications of drug-eluting technologies in other vascular beds are mentioned.
本文综述了药物洗脱装置在治疗外周动脉疾病方面的现有知识和应用。作者简要报告了普通球囊血管成形术和裸金属支架在股腘动脉及膝下病变中的表现。本文解释了药物洗脱装置研发背后的基本原理，并描述了目前可用的药物洗脱支架和药物涂层球囊的主要技术特征。专门章节讨论了研究这些装置在股腘动脉和腘下动脉血管床中潜在益处的试验结果。最后，提及了药物洗脱技术在其他血管床中的正在进行的研究和潜在的新应用。
