Saba Luca, Raz Eytan, Bassareo Pier P, di Martino Michele, de Cecco Carlo Nicola, Mercuro Giuseppe, Grassi Roberto, Suri Jasjit S, Piga Mario
Department of Radiology, Azienda Ospedaliero Universitaria (A.O.U.), Monserrato (Cagliari), Italy.
Department of Radiology, New York University School of Medicine, New York.
J Stroke Cerebrovasc Dis. 2015 Feb;24(2):284-9. doi: 10.1016/j.jstrokecerebrovasdis.2014.07.035. Epub 2014 Nov 22.
Cerebral microbleeds (CMBs) are small dot-like lesions appearing as hyposignals on gradient echo (GRE) T2* magnetic resonance (MR) sequences, whereas the leukoaraiosis (LA) indicates the presence of patchy areas of hypersignal on fluid-attenuated inversion recovery (FLAIR) MR sequences in the periventricular white matter. The purpose of this work was to evaluate the association between LA and CMBs.
Eighty-five consecutive (men 55; median age 64 years) patients were retrospectively analyzed using a 1.5 T system; CMBs were studied using a T2*-weighted GRE sequence and classified as absent (grade 1), mild (grade 2; total number of microbleeds, 1-2), moderate (grade 3; total number of microbleeds, 3-10), and severe (grade 4; total number of microbleeds, >10). LA was assessed with FLAIR MR sequences and was graded based on the European Task Force on Age-Related White Matter Changes as follows: 1 (no lesions), 2 (focal lesions > 5 mm), 3 (early confluent lesions), and 4 (diffuse involvement of an entire brain region).
We considered 170 cerebral hemispheres. The prevalence of CMBs was 24.7% (42 of 170), whereas the prevalence of LA was 27.1% (46 of 170). A statistically significant correlation was observed between LA and CMBs (correlation rho = .495, P value = .001). Multiple logistic regression analysis showed an association between CMBs and cerebrovascular symptoms (P = .0023).
Results of this study suggest an association between CMBs and LA. Moreover, we found that LA is associated with the presence of cerebrovascular symptoms.
脑微出血（CMBs）是在梯度回波（GRE）T2*磁共振（MR）序列上表现为低信号的小点状病变，而脑白质疏松（LA）是指在液体衰减反转恢复（FLAIR）MR序列上脑室周围白质出现片状高信号区域。本研究的目的是评估LA与CMBs之间的关联。
使用1.5T系统对85例连续患者（男性55例；中位年龄64岁）进行回顾性分析；使用T2*加权GRE序列研究CMBs，并将其分类为无（1级）、轻度（2级；微出血总数为1 - 2个）、中度（3级；微出血总数为3 - 10个）和重度（4级；微出血总数>10个）。使用FLAIR MR序列评估LA，并根据欧洲年龄相关性白质变化工作组的标准进行分级如下：1级（无病变）、2级（局灶性病变>5mm）、3级（早期融合病变）和4级（整个脑区弥漫性受累）。
我们共研究了170个大脑半球。CMBs的患病率为24.7%（170个中的42个），而LA的患病率为27.1%（170个中的46个）。观察到LA与CMBs之间存在统计学显著相关性（相关系数rho = 0.495，P值 = 0.001）。多因素逻辑回归分析显示CMBs与脑血管症状之间存在关联（P = 0.0023）。
本研究结果提示CMBs与LA之间存在关联。此外，我们发现LA与脑血管症状的存在有关。
