• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

辅助性 T 细胞主调控因子在炎症性皮肤病和原发性皮肤 T 细胞淋巴瘤中的表达：诊断意义。

Expression of helper T cell master regulators in inflammatory dermatoses and primary cutaneous T-cell lymphomas: diagnostic implications.

机构信息

Washington University Dermatopathology Center, Washington University School of Medicine, St. Louis, Missouri; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri.

Division of Dermatology, Washington University School of Medicine, St. Louis, Missouri.

出版信息

J Am Acad Dermatol. 2015 Jan;72(1):159-67. doi: 10.1016/j.jaad.2014.09.022. Epub 2014 Oct 18.

DOI:10.1016/j.jaad.2014.09.022
PMID:25440432
Abstract

BACKGROUND

Mycosis fungoides (MF) is a neoplasm of skin-homing CD4(+) helper T (TH) lymphocytes with dysregulation of TH1 and TH2 immunity. Diagnosis of MF is challenging, as there is significant morphologic overlap with other dermatologic entities.

OBJECTIVE

We investigated diagnostic utility of TH1- and TH2-specific markers, T-bet, and GATA-3, respectively, in MF and its reactive and neoplastic mimics.

METHODS

Immunohistochemical staining for CD3/T-bet and CD3/GATA-3 was performed on inflammatory dermatoses (n = 56), MF (n = 37), Sezary syndrome (SS; n = 8), and cutaneous anaplastic large cell lymphoma (C-ALCL; n = 14).

RESULTS

Inflammatory dermatoses showed epidermal T cells predominantly expressing GATA-3, except psoriasis, which exhibited a mixed GATA-3/T-bet staining. In contrast, neoplastic T cells in patch stage MF showed markedly increased T-bet positivity with minimal GATA-3 expression. Plaque stage MF had a mixed T-bet/GATA-3 phenotype, whereas tumor stage MF and SS exhibited diffuse GATA-3 expression. C-ALCL lacked significant staining for both markers.

LIMITATIONS

Sample size was relatively small.

CONCLUSIONS

A predominance of T-bet(+) T cells in the epidermis support patch stage MF over dermatitis. A predominance of GATA-3(+) T cells in the dermis support CD30(+) MF with large cell transformation over C-ALCL. These stains do not allow distinction between dermatitis and cutaneous infiltrates of SS.

摘要

背景

蕈样肉芽肿（MF）是一种皮肤归巢 CD4（+）辅助 T（TH）淋巴细胞的肿瘤，其 TH1 和 TH2 免疫失调。MF 的诊断具有挑战性，因为它与其他皮肤科实体有很大的形态重叠。

目的

我们分别研究了 TH1 和 TH2 特异性标志物 T-bet 和 GATA-3 在 MF 及其反应性和肿瘤性模拟物中的诊断效用。

方法

对炎症性皮肤病（n=56）、MF（n=37）、Sezary 综合征（SS；n=8）和皮肤间变大细胞淋巴瘤（C-ALCL；n=14）进行 CD3/T-bet 和 CD3/GATA-3 的免疫组织化学染色。

结果

炎症性皮肤病的表皮 T 细胞主要表达 GATA-3，但银屑病除外，其表现为混合 GATA-3/T-bet 染色。相比之下，MF 斑块期的肿瘤性 T 细胞 T-bet 阳性率显著增加，而 GATA-3 表达较少。MF 斑块期表现为混合 T-bet/GATA-3 表型，而肿瘤期 MF 和 SS 表现为弥漫性 GATA-3 表达。C-ALCL 两种标志物均无明显染色。

局限性

样本量相对较小。

结论

表皮 T 细胞中 T-bet（+）T 细胞的优势支持 MF 为斑块期而非皮炎。真皮中 GATA-3（+）T 细胞的优势支持 CD30（+）MF 伴大细胞转化而非 C-ALCL。这些染色无法区分皮炎和 SS 的皮肤浸润。

相似文献

1
Expression of helper T cell master regulators in inflammatory dermatoses and primary cutaneous T-cell lymphomas: diagnostic implications.辅助性 T 细胞主调控因子在炎症性皮肤病和原发性皮肤 T 细胞淋巴瘤中的表达：诊断意义。
J Am Acad Dermatol. 2015 Jan;72(1):159-67. doi: 10.1016/j.jaad.2014.09.022. Epub 2014 Oct 18.
2
Expression of T-follicular helper markers in sequential biopsies of progressive mycosis fungoides and other primary cutaneous T-cell lymphomas.蕈样肉芽肿及其他原发性皮肤T细胞淋巴瘤进展期连续活检中T滤泡辅助细胞标志物的表达
Am J Dermatopathol. 2015 Feb;37(2):115-21. doi: 10.1097/DAD.0000000000000258.
3
Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome): part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers.原发性皮肤 T 细胞淋巴瘤（蕈样肉芽肿和赛泽里综合征）：第一部分。诊断：临床和组织病理学特征以及新的分子和生物学标志物。
J Am Acad Dermatol. 2014 Feb;70(2):205.e1-16; quiz 221-2. doi: 10.1016/j.jaad.2013.07.049.
4
Immunologic Overlap of Helper T-Cell Subtypes 17 and 22 in Erythrodermic Psoriasis and Atopic Dermatitis.辅助性 T 细胞 17 型和 22 型在红皮病型银屑病和特应性皮炎中的免疫重叠。
JAMA Dermatol. 2015 Jul;151(7):753-60. doi: 10.1001/jamadermatol.2015.2.
5
Eosinophils in mycosis fungoides: an uncommon finding in the patch and plaque stages.蕈样肉芽肿中的嗜酸性粒细胞：在斑片和斑块期的一种罕见表现。
Am J Dermatopathol. 2012 Aug;34(6):586-91. doi: 10.1097/DAD.0b013e31823d921b.
6
Absence of T(H)2 cytokine messenger RNA expression in CD30-negative primary cutaneous large T-cell lymphomas.CD30阴性原发性皮肤大T细胞淋巴瘤中辅助性T细胞2细胞因子信使核糖核酸表达缺失
Arch Dermatol. 2001 Jul;137(7):901-5.
7
Cutaneous lymphocyte antigen expression in benign and neoplastic cutaneous B- and T-cell lymphoid infiltrates.皮肤淋巴细胞抗原在良性和肿瘤性皮肤B细胞及T细胞淋巴浸润中的表达
J Cutan Pathol. 2008 Nov;35(11):1040-9. doi: 10.1111/j.1600-0560.2007.00971.x. Epub 2008 Aug 4.
8
Differential NFATc1 Expression in Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoma and Other Forms of Cutaneous T-Cell Lymphoma and Pseudolymphoma.原发性皮肤CD4+小/中型多形性T细胞淋巴瘤及其他形式皮肤T细胞淋巴瘤和假性淋巴瘤中NFATc1的差异表达
Am J Dermatopathol. 2017 Feb;39(2):95-103. doi: 10.1097/DAD.0000000000000597.
9
Skewed expression of activation, differentiation and homing-related antigens in circulating cells from patients with cutaneous T cell lymphoma associated with CD7- T helper lymphocytes expansion.与CD7⁻辅助性T淋巴细胞扩增相关的皮肤T细胞淋巴瘤患者循环细胞中激活、分化和归巢相关抗原的表达失衡。
J Invest Dermatol. 1999 Oct;113(4):622-7. doi: 10.1046/j.1523-1747.1999.00718.x.
10
Expression of Th1 and Th2 cytokine-associated transcription factors, T-bet and GATA-3, in peripheral blood mononuclear cells and skin lesions of patients with psoriasis vulgaris.寻常型银屑病患者外周血单个核细胞及皮损中 Th1 和 Th2 细胞相关转录因子 T-bet、GATA-3 的表达。
Arch Dermatol Res. 2010 Sep;302(7):517-23. doi: 10.1007/s00403-010-1048-1. Epub 2010 Mar 24.

引用本文的文献

1
GATA3 as a Prognostic Marker in Early-Stage Classical Mycosis Fungoides: Association With Disease Progression and Survival Outcomes.GATA3作为早期经典蕈样肉芽肿的预后标志物：与疾病进展和生存结果的关联
Cancer Med. 2025 Sep;14(17):e71151. doi: 10.1002/cam4.71151.
2
Differential molecular programs of cutaneous anaplastic large cell lymphoma and CD30-positive transformed mycosis fungoides.皮肤间变大细胞淋巴瘤和 CD30 阳性转化蕈样肉芽肿的差异分子程序。
Front Immunol. 2023 Sep 18;14:1270365. doi: 10.3389/fimmu.2023.1270365. eCollection 2023.
3
Socs1-knockout in skin-resident CD4 T cells in a protracted contact-allergic reaction results in an autonomous skin inflammation with features of early-stage mycosis fungoides.
在持续性接触性过敏反应中，皮肤驻留CD4 T细胞中的Socs1基因敲除会导致一种具有早期蕈样肉芽肿特征的自主性皮肤炎症。
Biochem Biophys Rep. 2023 Aug 22;35:101535. doi: 10.1016/j.bbrep.2023.101535. eCollection 2023 Sep.
4
T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease.T 细胞细胞外陷阱：颠覆皮肤健康与疾病之间的平衡。
Front Immunol. 2022 Jun 20;13:900634. doi: 10.3389/fimmu.2022.900634. eCollection 2022.
5
TOX Outperforms FOXP3, CD4 and GATA3 in Histopathological Diagnosis of Early Mycosis Fungoides.在早期蕈样肉芽肿的组织病理学诊断中，TOX 优于 FOXP3、CD4 和 GATA3。
Turk Patoloji Derg. 2023;39(1):15-22. doi: 10.5146/tjpath.2022.01578.
6
Malignant and Benign T Cells Constituting Cutaneous T-Cell Lymphoma.构成皮肤 T 细胞淋巴瘤的恶性和良性 T 细胞。
Int J Mol Sci. 2021 Nov 29;22(23):12933. doi: 10.3390/ijms222312933.
7
The Role of Tumor Microenvironment in Mycosis Fungoides and Sézary Syndrome.肿瘤微环境在蕈样肉芽肿和塞扎里综合征中的作用
Ann Dermatol. 2021 Dec;33(6):487-496. doi: 10.5021/ad.2021.33.6.487. Epub 2021 Nov 4.
8
The Microenvironment's Role in Mycosis Fungoides and Sézary Syndrome: From Progression to Therapeutic Implications.《蕈样肉芽肿和塞扎里综合征中微环境的作用：从进展到治疗意义》
Cells. 2021 Oct 17;10(10):2780. doi: 10.3390/cells10102780.
9
Normal and cancer fibroblasts differentially regulate TWIST1, TOX and cytokine gene expression in cutaneous T-cell lymphoma.正常成纤维细胞和癌细胞在皮肤 T 细胞淋巴瘤中差异调节 TWIST1、TOX 和细胞因子基因的表达。
BMC Cancer. 2021 May 3;21(1):492. doi: 10.1186/s12885-021-08142-7.
10
Cellular Interactions and Inflammation in the Pathogenesis of Cutaneous T-Cell Lymphoma.皮肤T细胞淋巴瘤发病机制中的细胞相互作用与炎症
Front Cell Dev Biol. 2020 Sep 4;8:851. doi: 10.3389/fcell.2020.00851. eCollection 2020.