Vámos J, Brantner A, Józan M, Gracza I
Acta Pharm Hung. 1989 Mar;59(2):59-68.
Primary and secondary ion exchanges--of hydrochloric acid and hydrobromic acid salts of well hydrolyzing organic bases as well as quaternary ammonium bromide which are important drug substance--taking place on silica gel using methanol as mobile phase have been investigated by thin-layer chromatographic and spectrophotometric methods. In case of tertiary ammonium salts (hydrolyzing salts) basis linked to silanate ion and halogen acid have been formed by primary ion exchange. During secondary ion exchange halogen acid has exchanged metal ions linked to silanate ions on the layer. In case of non hydrolyzing salts, the quaternary ammonium bromide salts it could not surely be proved by the applied methods whether primary ion exchange had been followed by secondary ion exchange or only primary ion exchange had occurred.
利用甲醇作为流动相，通过薄层色谱法和分光光度法研究了在硅胶上进行的一级和二级离子交换，这些离子交换涉及水解性良好的有机碱的盐酸盐和氢溴酸盐以及作为重要药物原料的溴化季铵盐。对于叔铵盐（水解盐），通过一级离子交换形成了与硅烷酸根离子相连的碱和氢卤酸。在二级离子交换过程中，氢卤酸交换了层上与硅烷酸根离子相连的金属离子。对于非水解盐，即溴化季铵盐，应用的方法无法确切证明是先进行了一级离子交换后再进行二级离子交换，还是仅发生了一级离子交换。
